MVP Antikörper (N-Term)

Produktnummer ABIN2787778

Dieser Anti-MVP Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von MVP in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Kaninchen, Zebrafisch (Danio rerio), Hund, Pferd, Meerschweinchen und Schwein.

Kurzübersicht für MVP Antikörper (N-Term) (ABIN2787778)

Target: MVP (Major Vault Protein (MVP))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Zebrafisch (Danio rerio), Hund, Pferd, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MVP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MVP Antikörper

Bindungsspezifität: N-Term

Sequenz: MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MVP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MVP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 893 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MVP

Target: MVP (Major Vault Protein (MVP))

Andere Bezeichnung: MVP

Hintergrund: MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts.
Alias Symbols: LRP, VAULT1
Protein Interaction Partner: MVP, SKIL, TRIM27, REL, PLSCR1, MEOX2, MEOX1, MDFI, KPNA3, GOLGA2, DLX2, CAMK2B, AES, TRIP6, TRAF2, TP53, TFCP2, TCF4, SUMO2, NOTCH2NL, CCDC36, TRIM42, FAM154A, PIH1D2, RAB3IP, RIMBP3, C1orf94, RHOXF2, ZMIZ2, OBFC1, RFWD2, MKL1, VAC14, BANP, FAM46C, KCTD9
Protein Size: 893

Molekulargewicht: 98 kDa

Gen-ID: 9961

NCBI Accession: NM_005115, NP_005106

UniProt: Q14764